Founded in 1977 as part of a multinational French group, the company started its activity in 1978 with the production of liquid dosage forms (syrups, drinkable ampoules, and solutions). Two years later, production extended to solid dosage forms (coated tablets, capsules and lozenges) and semi-solid dosage forms (ointments, gels and suppositories).

In 1985 the company was purchased by a German group (Asta Medica). Following a new trend and market strategy, the group created several highly specialized centres. Regarding Sidefarma, the strategy consisted of a specialization in the production of small and medium batch sizes for Europe.

In 1994/95 the company reorganized its facilities in order to fully correspond to European demands regarding the manufacture of medicinal products (GMP guidelines). It was also awarded the ‘Galardão Mérito Empesarial’ by Câmara Municipal de Loures (Municipality of Loures).

Following this profound reorganization the company was granted, in May 1998, the NP EN ISO 9002:1995 certification with transition to NP EN ISO 9001:2000 in March 2004. The certification was renewed in March 2007. In 2009 the company renewed once again its certificate in conformity with ISO 9001:2008.

In 2001, Management-Buy-Out and separation came to happen and, since then, Sidefarma has been ensuring a sustained growth based on new management strategies.

In 2006 the company engaged into the area of injection medicinal products for hospital use. Today, the company presents itself as a trustworthy new partner to National Health System Hospitals as well as Private Health System Hospitals.

In February 2015, SIDEFARMA obtained Environmental Certification by NP EN ISO 14001: 2012, issued by the certifying body APCER. This certification ensures the suitability of SIDEFARMA's environmental management system, which aims to be a reference for the industrial sector in which it operates.